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The largest trial involving DSIP to date, which included a total of 107 volunteers, reported that the peptide was generally well-tolerated with mostly minor side effects, which included [8]: Low blood pressure Increased sweating Headache Nausea Vertigo Considering that the drop in blood pressure was reported as moderate to severe in some patients, researchers should consider hypotension as a potentially exclusionary criterion for DSIP research

Moreover, abnormal wound healing lays a foundation for various chronic diseases, including inflammatory disorders, fibrosis, and cancer [10]

Meanwhile, hydrophilic derivatives, namely SBE--CD and HP--CD, improve the solubility and bioavailability of poorly water-soluble drugs [51]

These findings were associated with the hippocampal gene expression of the brain inflammasome pathway, in which the Nod-like receptor protein 3 (NRLP3) genes and the antioxidant catalase were altered