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By disrupting the biofilm integrity, AC increases bacterial susceptibility to antibiotics and host immune responses, making it particularly effective in treating chronic and persistent infections where biofilms play a significant role (Zhang et al

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Sevarino, 2022)

By incorporating immune adjuvantssuch as cytokines, checkpoint inhibitors, or STING agonistswithin the hydrogel matrix, these systems deliver therapeutics directly to the tumor microenvironment, reprogramming immunosuppressive niches into immunostimulatory hubs [172]

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