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Although liraglutide activates GLP-1 receptors in the brain, the drug's weight loss effects are independent of GLP-1R activity in the hindbrain, area postrema, vagus nerve, and paraventricular nucleus

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Dos Santos Mello M, Ribas GS, Wayhs CA, Hammerschmidt T, Guerreiro GB, Favenzani JL, Sitta , de Moura Coelho D, Wajner M, Vargas CR (2015) Increased oxidative stress in patients with 3-hydroxy-3-methylglutaric aciduria