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Selective DPP4 inhibitors, glucoregulatory substrates, and the treatment of type 2 diabetes Interest in the therapeutic potential of inhibiting DPP4 for the treatment of metabolic disorders followed observations that GLP-1 [737]/GLP-1 [736] amide, and not GLP-1 [137], were potent glucose-dependent stimulators of insulin secretion (73), yet native GLP-1 [737]/[736] amide exhibited a very short circulating half-life, and continuous infusion was required to optimally control glycemia (139)
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It was then accidently discovered, in a patient using cyclosporine, that psoriasis had a strong immunological component
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Reinfection rate in a cohort of healthcare workers over 2 years of the COVID-19 pandemic
Thereafter, cells were washed once and incubated for 30 min at 37 with HBSS buffer (pH 7.4) supplemented with 0.1% BSA and 10 mM HEPES
