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Special populations and dose schedule adjustments Not every researcher fits the standard profile studied in clinical trials

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In the case of all-cause mortality, a multinational cohort study with over 2 million patients with T2DM receiving insulin and a follow-up time of 5 years showed a significant reduction in all-cause mortality in those with SGLT-2i and GLP-1RA combination therapy as compared to those treated with either SGLT-2i or GLP-1RA alone [50]