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1, 2, 3 These receptors have increasing clinical importance as, on one hand, they mediate the action of commercially available GLP1 analogs such as exenatide or liraglutide to help treat diabetes patients 4, 5, 6 and, on the other hand, represent the targets for radiolabeled GLP1 or exendin to visualize in vivo insulinoma tumors

That could lead to a change in the Fed's reaction function

FDA-approved tesamorelin is contraindicated in active malignancy and requires careful risk assessment in patients with a history of cancer