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What MOTS-c Is and Why It Declines With Age MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a peptide encoded in the mitochondrial genome, not the nuclear genome

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Mechanistic and Translational Research Further investigation into the molecular mechanisms of action could help optimize clinical applications and identify novel therapeutic targets

This is one mechanism linking methylation dysfunction to elevated catecholamines, histamine intolerance, and impaired xenobiotic clearance

Harrison SA, Frias JP, Lucas KJ, Reiss G, Neff G, Bollepalli S, Su Y, Chan D, Tillman EJ, Moulton A, de Temple B, Zari A, Shringarpure R, Rolph T, Cheng A, Yale K

Wood LG, Gibson PG, Garg ML