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Now heres where things get interesting, certain compounds can actually enhance this pathway

As the disease progresses, the overlying skin can be thicker and distorted

Dietary Fiber Since butyrate-producing bacteria feed upon dietary fiber, dietary supplementation with fiber may provide a feasible option to increase the levels and the activity of the bacteria, and increase the intestinal levels of butyrate

Proc Natl Acad Sci USA (2019) 116:2224651

So you have the recognition, which is just something people begin observing that diabetics on these drugs begin to lose weight and they dont feel hungry