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34 Initial dosing regimen of Byetta is 5 g subcutaneously twice daily and after one month, the dose is increased to 10 g twice daily based on clinical response (Table 1)

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Seek medical attention if you experience: Persistent numbness Severe wrist nerve pain Weakness in the hand These signs indicate advanced carpal tunnel symptoms

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When compared with placebo or other therapies, GLP-1 agonists were associated with an increased risk of biliary disease [23]: Overall biliary disease: RR 1.37(95% CI 1.231.52) Cholelithiasis: RR 1.27 (95% CI 1.101.47) Cholecystitis: RR 1.36 (95% CI 1.141.62) Mechanisms: Reduced gallbladder motility Rapid weight loss increased cholesterol saturation and gallstone formation

7 , R380R391 (2005)