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Rassaf T, Preik M, Kleinbongard P, Lauer T, Heiss C, Strauer BE, Feelisch M, Kelm M

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The IGF-1/p53-mediated cellular senescence (see above) might also be induced by the STAT3/SOCS pathway

This type of metabolite ratio analysis can increase diagnostic efficacy by detecting changes not apparent when using an analysis of individual metabolites thereby providing information on biological processes that may not be discerned when studying only metabolite levels (34)