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Through endocytic delivery by transfectants, cytoplasmic DNA sensors activate interferon regulatory factor 3 (IRF3) via either the cyclic guanosine monophosphateadenosine monophosphate (cGAMP)STING or receptorinteracting serine/threonineprotein kinase 1/3 (RIPK1/3) signaling cascades, ultimately leading to the production of IFN - [120,121,122]

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The selective vulnerability in females led the authors to hypothesize a role for estrogen-linked mechanisms, although this was not tested

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