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Wiehle R, Cunningham GR, Pitteloud N, Wike J, Hsu K, Fontenot GK, Rosner M, Dwyer A, Podolski J

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Emerging evidence indicates that vitamin D, through receptor-mediated signaling, participates in multiple pathophysiological processes, including the regulation of immune and inflammatory responses, the mitigation of oxidative stress, the preservation of mitochondrial function, the inhibition of renal fibrosis, modulation of the reninangiotensinaldosterone system (RAAS), and the maintenance of gutkidney axis homeostasis

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To integrate digital decision support systems into the everyday life of PHB patients, we need to ensure that they are based on the best evidence for safety, efficacy and utility