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Key Areas of Scientific Interest: Modeling of tendon & ligament recovery responses Evaluation of gastroprotective signaling Studies on cellular resilience under oxidative conditions Tissue repair and regeneration frameworks For Research Use Only This material is not intended for clinical, diagnostic, dietary, or therapeutic use

Nature 521, 489494

Cloyd, J

What they found (summary): Amylin is a critical partner of insulin in metabolism, the loss of amylin in T2DM is as significant as the loss of insulin The AMY1 receptor in the area postrema is the primary target for the appetite effect Amyloid aggregation is the main problem with native amylin, proline substitutions (the Pramlintide strategy) are essential The half-life of native amylin is only 13 minutes, that is why lipidated analogs like Cagrilintide are necessary Perspective: amylin + GLP-1 combinations are the natural evolution of metabolic pharmacotherapy Why it matters: This is the reference article for amylin pharmacology

doi: 10.3390/biom10101367 75 FinneyJ.MoonH.-J.RonnebaumT.LantzM.MureM

This interest in the biological significance of H 2 S and research on its endogenous synthesis and catabolism was reflected in a large increase in the number of publications regarding this topic (Figure 1)