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[DOI] [PubMed] [Google Scholar] 8.Sikiric P., Seiwerth S., Rucman R., Kolenc D., Vuletic L.B., Drmic D., Grgic T., Strbe S., Zukanovic G., Crvenkovic D., et al

It signals that the approved use is chronic management rather than a defined course with an end date, which reframes the question from "how long until I finish" to "how long until the trajectory is established, and what happens after." An Intermediate Marker Around Five Months The clearest published mid-course number comes from STEP 4, which used a 20-week run-in 16 weeks of dose escalation plus four weeks at the maintenance dose before randomizing participants

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