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In addition to catalytic functions, DPP4 also interacts with different types of ligands, including adenosine deaminase (ADA), caveolin-1, fibronectin, and C-X-C chemokine receptor type 4 (CXCR4) (1)

One contributing factor is the lower abundance of various ureolytic bacteria in the rumen such as Succinivibrionaceae and Ruminococcaceae 27

Clinical trials have shown that this leads to a 30-40% reduction in food intake compared to baseline

If side effects persist intensely beyond week four, genetic factors affecting peptide metabolism (detectable through PlexusDx Precision Peptide Genetic Test at $99 after first month) may influence your response, helping your provider optimize your dose or compound

Insulin action also results in reduced phosphorylation of GS via activation of protein phosphatase 1 (PP1)

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