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It was initially isolated from the brains of rabbits and is named for its ability to induce delta-wave activity in EEG recordingsan indicator of deep, restorative sleep

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Concentrations decline sharply with age: plasma levels drop from roughly 200 ng/mL at age 20 to under 80 ng/mL by age 60

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Research shows that both naturally aged wildtype mice and fast-aging XpdTTD/TTD mice develop progressive kidney dysfunction characterized by elevated plasma urea and creatinine levels, established biomarkers of reduced glomerular filtration capacity