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Methods Protein expression and purification CDK11-cyclin L-SAP30BP Synthetic, codon optimised genes encoding CDK11B, cyclin L2, and SAP30BP (Twist Bioscience) were cloned into 438-series vectors for baculovirus-based expression in insect cells 57 , resulting in a multi-protein construct expressing Twin-Strep-tagged CDK11B p58 (CDK11B p110 residues 357795), His 6 -tagged Cyclin L2 (1319), and MBP-tagged SAP30BP (Supplementary Fig

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Individual results vary, and cross-product equivalence shouldn't be inferred - what a particular compounded prescription will do for you is a separate, unestablished question that belongs to your prescribing clinician