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Inhibitors do not convert TGR into an NADPH oxidase Several covalent inhibitors of TGR are electrophilic compounds reacting with the Sec residue at the C-terminus, which induce a transition in the enzyme from an antioxidant to a pro-oxidant with increased NADPH consumption 20,45

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This variant is located in the GLP1R gene, which codes for the receptor protein that is the target of GLP-1 medications

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The complaints raise claims including failure to warn, negligence, defective design, and violations of consumer protection laws