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We thank the Shanghai Municipal Government, ShanghaiTech University and GPCR Consortium for financial support

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Neurons are exquisitely sensitive to oxidative stress and require high levels of NADPH to generate antioxidant defense systems regulated by GSH and Trx

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The effectiveness of once-daily subcutaneous liraglutide administration for weight loss management in adults was established in five large-scale randomized multicentre phase 3 trials [49,50,51,52,53], four of which were part of the SCALE program (Satiety and Clinical AdiposityLiraglutide Evidence in nondiabetic and diabetic individuals), leading to its approval at a dose of 3.0 mg subcutaneous once-daily (weekly increased from 0.6 mg to 3 mg/day)