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In SURPASS trials, patients on metformin plus tirzepatide achieved HbA1c reductions of 2.0-2.5%, with many reaching HbA1c targets below 5.7% (normal range)

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A study in Labrador Retrievers found that dogs supplemented with L-carnitine showed decreased food intake, increased basal metabolic rate, and greater weight loss compared to unsupplemented dogs particularly at higher doses

The weight loss associated with tirzepatide requires individualized assessment in celiac patients

While C peptide reflects the -cell secretory capacity, its hepatic extraction, unlike that of insulin, is negligible (43, 44)

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