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These medications help many patients feel fuller longer, reduce cravings, and support gradual, sustainable weight loss when combined with lifestyle changes

Tirzepatide works for weight loss and blood sugar as well

Long-term safety data of retatrutide is still unknown

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In a recent phase II trial with subcutaneous semaglutide, when doses were escalated relatively rapidly to 16 mg weekly, participants experienced additional weight loss, but at the expense of more adverse effects (21)

Nausea affects 2044% of users, vomiting 1025%, diarrhea 1520%, constipation 1015%