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In a model of chronic stress caused by social isolation, depressive-like behaviors have been observed along with increased corticosterone levels, decreased adrenocorticotropic hormone, and decreased serum antioxidant capacity 32

Hvistendahl MK, Naimi RM, Enevoldsen LH, Madsen JL, Fuglsang S, Jeppesen PB

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Most clinical recommendations for patients in a caloric deficit who are trying to preserve lean mass fall in the range of 1.2 to 1.6 grams per kilogram of body weight, with some sports medicine guidelines suggesting up to 2.0 grams per kilogram for patients doing regular resistance training