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Gallego-Lopez MDC, Ojeda ML, Romero-Herrera I, et al

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This density is consistent with a covalently bound closed D-ring (termed the C 5 H 5 O 2 modification) 42,55,57 , but not with the open CLIM linked to both S95 and H246, as proposed for the ASK1 Os D3 At D14 crystal structure (PDB 5HZG) (Supplementary Fig

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4

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After 30 min incubation, cAMP levels were measured using the cAMP dynamic 2 HTRF kit (Cisbio) following manufacturers recommendations

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