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Most insurers cover testosterone replacement therapy for clinically low levels but exclude growth hormone secretagogues for anti-aging or performance purposes

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Several alternative therapeutic strategies have been investigated, including protein kinase C inhibitors [10], darbepoetin alfa [11], endothelin receptor antagonists (ERAs) [12], direct renin inhibitors [13], nuclear factor erythroid 2-related factor 2 activators [14], and combination of ACE inhibitor and ARB [15]