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If neurological symptoms are present, treatment may involve 1mg injections on alternate days until no further improvement is seen, followed by maintenance therapy

The combined cost of CagriSema may exceed the cost of retatrutide monotherapy, even though retatrutide requires higher individual doses

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SGLT2is are recommended if eGFR is 20 mL/min/1.73 m 2 to reduce progression of CKD and risk of CVD, with the KDIGO and ADA guidelines also adding that patients are to have a UACR 200 mg/g [6, 18, 20, 84]