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Moreover, hydrogel spacers not only protect normal tissue mechanically, but they also serve as a platform for combinatorial interventions, such as embedding radiosensitizers or immunomodulatory agents, thereby integrating organ protection with active tumor-targeted therapy [146, 166]

Additionally, recent data recognized visceral fat as a risk factor for postoperative recurrence in CD patients (76)

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Obesity and type 2 diabetes: adiposopathy as a triggering factor and therapeutic options