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doi: 10.1001/jamacardio.2018.0022 20 GuhDPZhangWBansbackNAmarsiZBirminghamCLAnisAH

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Theres also evidence from the Phase 2 trial data suggesting Retatrutide may favorably affect lean mass composition compared to bodyweight loss alone, though long-term Phase 3 data on this specific metric will be more definitive

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For semaglutide (Wegovy), the STEP trial program enrolled over 4,500 participants across multiple studies, with safety monitoring extending up to 68 weeks

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If semaglutide is appropriate for you, your provider will establish a starting dose and a titration schedule designed to maximize effectiveness while minimizing GI side effects

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