The geneenvironmentepigenome axis thus provides a compelling framework for understanding the molecular underpinnings of this comorbidity [12, 277,278,279,280,281]
Each form of B12 works along different biological pathways within the body
ALLO impairs memory acquisition/encoding in rodent models when it is injected into the nucleus basalis magnocellularis before an acquisition trial, implicating inhibition of cholinergic neurotransmission in the effects of ALLO on memory acquisition (181)
Acknowledgements The authors are supported by National Institute of Diabetes and Digestive and Kidney Disease grants R01DK61931 and R01DK68271 (J.R.T.), U.S
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