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Furthermore, research continues in peptide science, and cellular biology

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If the proposed mechanism (gradual synaptic plasticity effects) is right, daily dosing might be needed for sustained effect

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There are no other absolute contraindications reported for hydroxocobalamin use in deficiency states, but caution is advised in individuals with conditions such as early Lebers optic neuropathy (a rare hereditary optic atrophy) due to the theoretical risk of worsening vision