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Combinatorial presentation of cartilage-inspired peptides on nanopatterned surfaces enables directed differentiation of human mesenchymal stem cells towards distinct articular chondrogenic phenotypes

However, they also have limitations: many are unstable in the gut, so they are often given by injection, and some have limited human data outside of specific indications

Above pH 7.0, hydrolytic cleavage rates increase significantly

Alternatively, systemic abdominal injection allows the peptide to migrate to the carpal tunnel area

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