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Pairing it with two incretin arms is intended to let the thermogenic and hepatic effects of GCGR signalling proceed while the GIP and GLP-1 arms counterbalance the glycaemic consequence

Using a 90-degree angle, pinching the skin, and choosing sites with adequate fat reduces this risk

Physicians should inquire about these problems and monitor for them during therapy

The fatigue typically peaks 4 to 8 hours after injection and can linger for 24 to 48 hours

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Cardiovascular Biology of the Incretin System