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However, tirzepatide may cause higher rates of gastrointestinal side effects, particularly during the initial dose titration stage

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In the mediation analyses, which examined change in HbA 1c and BW (both separately and combined) as potential mediators for the effect of semaglutide on hsCRP, the effect on hsCRP was partially mediated via the effect of semaglutide on HbA 1c and BW, although HbA 1c seemed to contribute slightly more than BW

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[2] Individual circumstances matter significantly