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31 GiangregorioN.TonazziA.ConsoleL.LorussoI.De PalmaA.IndiveriC

Glutathione down-regulated in Parkinson's disease Key metabolites were identified using LCMS/MS, with a focus on metabolic pathways relevant to Parkinson's disease (PD), including energy metabolism, lipid metabolism, and amino acid metabolism

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Their study demonstrated that this metabolic shift supports the hyper-proliferative and apoptosis-resistant phenotype by inhibiting AMPK and activating the AKT/mTOR signaling axis

344 Iron overload may trigger an inflammatory response through activating the NF-B pathway and inducing the secretion of inflammatory factors such as IL-1, TNF-, and IL-6