For a drug administered orally, bioavailability may be less than 100% for two main reasonsincomplete extent of absorption across the gut wall and first-pass elimination by the liver (see below)
Background We refer readers to the CY 2025 OPPS/ASC final rule with comment period (89 FR 94563) for the previously estimated effects of changes to the ASCQR Program for the CY 2025 reporting period and subsequent years
Cell 169.1 (2017): 132-147.e16
Thus, a one-size-fits-all treatment phase is just not appropriate for patients of all ages, statures, and biological frames
Genome Res 14:18061811 Prabhakar R, Vreven T, Morokuma K, Musaev DG (2005) Elucidation of the mechanism of selenoprotein glutathione peroxidase (GPx)-catalyzed hydrogen peroxide reduction by two glutathione molecules: a density functional study
Given this situation it is particularly concerning that MDA campaigns show that PZQ cure rates are often less than 50% and modeling studies demonstrating that these campaigns with PZQ alone are unlikely to interrupt transmission, and once MDA is suspended, the prevalence of infection is likely to rebound to pre-MDA levels 9,10,11
