Future directions First, define exposureresponse with quantitative pharmacokinetics and, where possible, receptor-occupancy or target-engagement biomarkers to guide dose selection across tissues
Factors influencing the outcome include individual metabolism, lifestyle choices and diet
In observational studies, rectal cancer patients with diabetes treated with metformin during their cancer treatment, either neoCRT or peri-operative chemotherapy, have demonstrated higher rates of pCR, when compared to those patients not receiving metformin (27)
Most of the these are repurposed (95%), so the number of available marketed products is not a reflection of targeted product development
Immunohistochemical analysis of biopsy and postmortem samples revealed increased expression of UPR markers, including CHOP and BiP, in oligodendrocytes, astrocytes, T cells, and macrophages/microglia within MS lesions
Neurobiology of Aging, 35(Suppl 2), S55-S64.
