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In the STEP UP clinical trial, participants taking 7.2 mg of semaglutide once weekly lost an average of around 21% of their starting body weight over 72 weeks when the medication was combined with lifestyle changes such as a reduced-calorie diet and increased physical activity

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Phentermine/topiramate, while offering potential benefit as an adjunct, is limited by its adverse effect profile

J.ZhangS.JohnsonC.KimberC.et al (2016)