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The two compounds activate distinct somatotroph receptors (GHRH-R and GHS-R1a), producing additive GH release in published rodent and primate models without the cortisol or prolactin spillover seen with earlier GHRPs, because they couple to different intracellular signalling cascades

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Kaku K, Yamada Y, Watada H, Abiko A, Nishida T, Zacho J, Kiyosue A