Our view: Oral GLP-1 supplementation, combined with good nutrition and consistent habits, is the more evidence-supported non-prescription option
J.Fernndez LandL.et al (2021)
GLP-1s are highly effective at controlling blood sugar and slowing down gastric processes, but they are also highly effective (so to speak) at bringing on side effects like constipation, nausea, and abdominal pain that, if untreated, will impact adherence and, in turn, short and long term results
Therefore, drugs with a potent antihyperglycemic effect, independent of the glomerular filtration rate, with a low risk of hypoglycemia, that reduce weight in overweight/obese patients and that provide cardiovascular and renal protection, such as GLP-1 receptor agonists, are needed
Combined metformin and exenatide versus only metformin treatments in polycystic ovary syndrome with abdominal obesity and network pharmacology of gene expression: evidence from a randomized clinical trial
Extended absence of bowel movements can lead to fecal impaction, a condition where hardened stool becomes lodged in the rectum or colon and cannot be passed without medical intervention
