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This biological framework supports the hypothesis that androgen status may influence skeletal muscle resilience during sustained weight reduction, as illustrated in Figure 2

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In inflammatory breast cancer, it is instrumental in driving a chemotherapy-tolerant, stem-like cell state [48], The therapeutic potential of targeting such survival networks is highlighted by agents like the multi-target inhibitor Lestaurtinib, which demonstrates efficacy against both therapy-sensitive and -resistant ovarian cancers by converging on key nodes including JAK/STAT [49]

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Glutathione is also a precursor of many detoxifying enzymes, including glutathione peroxidase responsible for neutralising waste products from cellular respiration or the process of cell death (apoptosis) (5)

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