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Some factors may affect your risk of sagging skin after weight loss using medications such as injectable semaglutide (Ozempic, Wegovy)

IGF-1 is known to increase sebum (oil) production and has been associated with inflammation in the skin, both of which are factors in acne development

Environmental medicine theories suggest this binding triggers immediate and severe mast cell degranulation, forcing the cells to dump massive amounts of histamine, cytokines, and leukotrienes into the bloodstream

[10] When increased intra-abdominal pressure is repeatedly applied during defecation, it can cause swelling and inflammation of the vascular cushions in the anal canal, leading to symptomatic haemorrhoids

Supports reduction of dark spots and dullness