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Patients in the dataset had a 2.56 times higher rate of developing NAION within 1 year after starting a GLP-1 receptor agonist than those in the dataset who started a dipeptidyl peptidase-4 (DPP-4) inhibitor

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Its varied potential mechanisms are thought to include interaction with inducible and/or endothelial nitric oxide-generating systems, by influencing serotonin, dopamine, GABA, and/or opioid metabolism, and/or by directly aiding blood flow, repair, regrowth, angiogenesis, and remodeling