Higher doses have a stronger effect on gastric emptying and colon motility, leading to more frequent and severe digestive disruptions
Diabet Med 15:651656 Carter D, Howlett HC, Wiernsperger NF, Bailey CJ (2003) Differential effects of metformin on bile salt absorption from the jejunum and ileum
[DOI] [PubMed] [Google Scholar] 55.Kraemer W.J., Spiering B.A., Volek J.S., Ratamess N.A., Sharman M.J., Rubin M.R., French D.N., Silvestre R., Hatfield D.L., Van Heest J.L., et al
No long-term human safety data exists
A magnetic covalent organic framework as an adsorbent and a new matrix for enrichment and rapid determination of PAHs and their derivatives in PM(2.5) by surface-assisted laser desorption/ionization-time of flight-mass spectrometry
Next, comprehensive sensitivity analyses were conducted to ensure robustness, including heterogeneity testing, pleiotropy assessment, and leave-one-out validation