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A study by the UK Prospective Diabetes Study Group has shown that long-term intensive glucose control could reduce mortality rate, possibly due to the potential benefit of these medications [37]

In addition, magnesium, riboflavin, niacin, and thiamine (vitamin B1) also contribute to normal energy metabolism, while magnesium, niacin, and thiamine additionally support normal psychological function 1

Notable concerns with metformin use include lactic acidosis and intolerable gastrointestinal upset

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