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GPR-120 is expressed by chondrocytes in culture [46], and its role in OA was investigated by inducing the ACLT post-traumatic OA model in GPR-120knockout mice

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Metformin has been found to produce antidepressive effects by enhancing the responsiveness of the serotoninergic neurons in the dorsal raphe [47], but the main impact of GLP-1 is exerted by AMP-activated protein kinase (AMPK), a major cellular regulator of lipid and glucose metabolism [48]

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TGR5 inhibition of glycogenolysis in hepatic tissue is dependent on GLP-1 activity, as coadministration of a TGR5 agonist and GLP-1 antagonist abolished the suppression of hepatic glycogenolysis [140]