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These gut-focused mechanisms are particularly relevant for autoimmune diseases with gastrointestinal involvement, but researchers increasingly believe that gut barrier integrity influences autoimmune activity far beyond the digestive tract

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Although many treatments effective in animal models of IRI have failed to translate into clinical use, glucagon-like peptide 1 (GLP-1) and the GLP-1 receptor (GLP-1R) agonist exenatide have shown benefits in IRI in both animal models (47) and small early-phase clinical trials (8, 9)

If cirrhosis has not developed, the liver can heal itself if alcohol consumption is stopped

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