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Animal models of osteoarthritis: classification, update, and measurement of outcomes
[12] Cannabinoids [edit] Cannabinoids are the compounds found in cannabis, which is a euphoriant and hallucinogenic drug prepared from the dried leaves of the strong-smelling plant Cannabis sativa
--- 5 Dosage Initial dose: 5 mg once daily (usually at bedtime) After 46 weeks Increase to 10 mg daily Severe cases: up to 23 mg daily (extended-release form) --- 6 Adverse Effects Common: Nausea Vomiting Diarrhea Insomnia Muscle cramps Fatigue Serious: Bradycardia Syncope GI bleeding QT prolongation (rare) Due to increased cholinergic activity
The Verdict: Potent for inflammation and flexibility, but strictly an experimental intervention in humans
Usage Cited in: Hortic Res
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