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Direct head-to-head comparisons remain limited, but subgroup analyses suggest tirzepatide may produce fewer severe nausea events requiring dose interruption

Prospective survey on the natural course of restless legs syndrome over two years in a closed cohort

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The STEP 4 trial led by Domenica Rubino showed that the effect depends on continuation: participants switched to placebo regained roughly two-thirds of their lost weight over the following year (Rubino et al., 2021)

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However, brand-name options like Ozempic and Wegovy often cost $900 to $1,400 monthly, making them inaccessible for many