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The main drawbacks of such methods are the difficulty of achieving cell type-specific profiling if suitable surface markers (that can be targeted by antibodies) are unavailable and, for future applications, the challenge of delivering large antibody reagents and high-intensity light into animals and tissue

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In a healthy metabolic system, cells respond readily to insulins signal, blood sugar stays stable, and the pancreas produces modest amounts of insulin to maintain balance

Discontinuation rates due to side effects were around 710% at the highest dose