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However, research in young, cognitively healthy adults shows limited or no cognitive enhancement, suggesting benefits are most pronounced in individuals with age-related decline, metabolic stress, or neurodegenerative pathology

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At the cellular level, coptisine exerts dose-dependent cytotoxicity in HepG2 and 3T3-L1 cells, with IC 50 values of 64.81 g/mL and 56.48 g/mL, respectively, showing cytotoxicity only at relatively high concentrations (Yi et al., 2013)

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