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Their activity depends on maintaining an intact molecular structure, which can be affected by time and handling

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Some studies conducted in rodents, with exanatide and liraglutide, showed an association regarding the development of thyroid C-cell tumors after long exposures to overtherapeutic doses ( in vivo studies in cynomolgus monkeys administering liraglutide showed no effect on the relative fraction of C cells in the thyroid gland after 87 weeks